Nanomolar CFTR Inhibition by Pore-Occluding Divalent Polyethylene Glycol-Malonic Acid Hydrazides
نویسندگان
چکیده
منابع مشابه
Discovery of Glycine Hydrazide Pore-occluding CFTR Inhibitors
The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a cAMP-regulated epithelial Cl- channel that, when defective, causes cystic fibrosis. Screening of a collection of 100,000 diverse small molecules revealed four novel chemical classes of CFTR inhibitors with Ki < 10 microM, one of which (glycine hydrazides) had many active structural analogues. Analysis of a series of syn...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2008
ISSN: 1074-5521
DOI: 10.1016/j.chembiol.2008.05.015